Evorel sequi summary of product characteristics smpc emc. Appendix 12 hrt preparations west midlands menopause. Some of the dosage forms listed on this page may not apply to the brand name femseven sequi phase i. Femseven sequi, patch is not a transdermal contraceptive and does not prevent you from becoming pregnant. Gps may need to switch patients hrt as shortages set to increase. Lenzetto is an estradiol metereddose transdermal spray. The transdermal contraceptive patch is a highly effective form of estrogenprogestin contraception. How to properly apply a transdermal patch duration. Evorel sequi oestradiolnorethisterone transdermal patches 50mcg170mcg twice weekly first line transdermal treatment option femseven sequi oestradiollevonorgestrel transdermal patches 50mcg10mcg once weekly skin allergy poor absorption with evorel, alternative adhesives oestradiol tablet patchgel as above plus adjunctive progestogen.
Evorel sequi oestradiolnorethisterone transdermal patches 50mcg170mcg twice weekly first line transdermal treatment option femseven sequi oestradiollevonorgestrel transdermal patches 50mcg10mcg once weekly skin allergy poor absorption with evorel, alternative adhesives oestradiol tablet patch. The birth control patch is a thin,stickon, square, 4 inch patch that allows hormones to enter the blood stream through the skin. This will give an equivalent transdermal oestrogen delivery with an alternative progestogen. Estradiollevonorgestrel patch, transdermal weekly webmd. As femseven patches contain only oestrogen, they are most suitable for women who have had a hysterectomy. Femseven conti and femseven sequi transdermal hrt adhesive patched. Transdermal estrogens avoid firstpass metabolism which allow transdermal. The patches are transdermal and are applied to areas of. Three consecutive patches are used for a total of 21 days, followed by a patch free week, during which time scheduled.
Patchtransdermal contraception klickitat county, wa. Both evorel 50 and evorel conti are a transdermal delivery system tds, or transdermal patch, composed of a flat twolayer laminate. Hormone replacement therapy hrt shortages in the uk. You wear the patch on certain parts of your body, and it releases hormones through your skin that prevent pregnancy.
Scottish medicines consortium smc 10 january 2003 indication. British menopause society further update on hrt supply shortages. It contains two different female hormones, oestrogen in the form of estradiol and progesterone in the form of norethisterone. Femseven conti offers an alternative continuous combined hormone replacement therapy hrt for the treatment of oestrogen deficiency symptoms in postmenopausal women more than one year after menopause.
Buy femseven combined hormone replacement therapy online. Femseven sequi patches are octagonal, transparent, flexible, roundededge transdermal matrix patches located on an oversized removable protective liner. Women who had been taking the combined patch may now have to switch to an oestrogenonly patch and take. Sequential or cyclical therapy is also available as a transdermal patch. One femseven sequi patch should be applied once each week to a clean, dry, unbroken, nonirritated area of skin below the waist, preferably on the buttock or hip. Evorel sequi is a hormone replacement therapy that comes as a transdermal patch. Apply 1 patch once weekly for 2 weeks, phase 1 patches to be applied, then apply 1 patch once weekly for 2 weeks, phase 2 patches to be applied, subsequent courses are repeated without interval.
This new transdermal contraceptive system contraceptive patch, evra janssencilag. Patient counselling is advised for estradiol with levonorgestrel patches application. The medicines and healthcare products regulatory agency granted a marketing authorisation valid throughout the european union for lenzetto on august 2015. Elleste solo mx patches 40mcg transdermal estradiol available. Femseven conti patches are intended for women who are no longer in the fertile age bracket. It is formulated as a transdermal patch and is the first continuous combined hrt patch. Having transdermal oestrogen, so oestrogen through the skin as a. Transdermal patches are a relatively new development in hormonal contraception.
Most women who desire a reversible, noneventbased method of contraception and who have no contraindications to use of estrogens or progestins can safely use this method. It contains two female hormones an oestrogenestradiol and a. The phase one patches contain estradiol previously spelt oestradiol in the uk. Shortage of hrts femseven conti and sequi expected until 2020. Women with an intact womb should also be prescribed a progestogen medicine to take with this medicine to oppose oestrogens effect on the womb lining and reduce the risk of endometrial cancer. All estrogenprogesterone combination contraceptives carry a risk of thrombophlebitis and thromboembolitic disease ted with the majority of the risk attributable to the. Theramex holds the marketing authorization for femseven conti and femseven sequi. Ive been trying to get the femseven sequi patches for a couple of weeks now.
Been on them a year they make me feel like me again. Estradiol with levonorgestrel drug bnf content published. Apply 1 patch twice weekly continuously, started within 5 days of onset of. Like birth control pills, a combination of hormones in the patch stops your body from releasing an egg, so no eff can be fertilized. The adhesive and the sex steroids are mixed together in the middle layer. If you forget to take femseven sequi, patch patient. Femseven sequi patches estradiol, levonorgestrel netdoctor. There can be variation in the licensing of different medicines containing the same drug. Transdermal preparations of estrogen are metabolized differently than oral preparations. Estradiol 50g levonorgestrel 10g quarterly bleed hrt oral tridestra. Evorel sequi is a continuous sequential hrt preparation. They are used to treat women with menopausal symptoms.
Femseven conti and femseven sequi transdermal patches are currently out of stock due to a supply problem with a component of the adhesive and there will be a period of testing before the transdermal patches are commercially available again. Femseven sequi should be applied to an area of skin without major skin folds, e. Femseven sequi patches should be used with caution by women with a risk of developing cancers that are stimulated by oestrogen, for example women whose mother or sister has had breast cancer. Femseven sequi is suitable for postmenopausal women. You use the phase one patches for the first two weeks and the phase two patches for the second two weeks of each monthly cycle. Femseven conti patches are a hormone replacement therapy hrt preparation. Evorel sequi summary of product characteristics smpc. Both evorel 50 and evorel conti are a transdermal delivery system tds, or transdermal patch, composed of a flat twolayer laminate which is 0. Abnormal development of the lining of the uterus endometrial hyperplasia.
I started using femseven conti patches about 6 weeks ago patches great but two days after patch 4 i started bleeding with period pains and still bleeding now week 6 and due to change patch on saturday week 7. The phase one patches contain estradiol and are used during the first two weeks of every monthly cycle. Meanwhile, all strengths of femseven conti and sequi estradiollevonorgestrel patches have. It belongs to a group of medicines called hormone replacement therapy hrt. Combination hrt transdermal patches for women using evorel conti and sequi patches, the only other combination transdermal patches on the market are femseven conti and sequi containing estradiol and a different progestogen, levonorgestrel. British menopause society further update on hrt supply.
Contraceptive transdermal patch online uk pharmacy. Femseven sequi patches are a hormone replacement therapy hrt. Femseven sequi estradiollevonorgestrel patches 12 is a hormone replacement therapy hrt used to relieve symptoms of menopause. An estrogen patch oestrogen patch is a transdermal delivery system for estradiol, which can be used as hormone replacement therapy to treat menopause symptoms, hypoestrogenism, and to prevent osteoporosis.
Transdermal estradiol 50mcg24hrs transdermal levonorgestrel 10mcg24hrs for 14 days28. Evorel sequi estradiol 50 micrograms norethisterone 170 micrograms c19 femseven sequi estradiol 50 micrograms levonorgestrel 10 micrograms c19 consider patches if liver disease or previous history of dvtpe see overleaf major caution. A spokesperson for themex said the shortage of its femseven conti and sequi products relates to quality issues with the adhesive that keeps the patches attached to the skin. An observational study suggests that women using the transdermal contraceptive patch. Each phase 1 patch 1st and 2nd week of the patients cycle contains 1. What femseven sequi patches look like and contents of the pack benign breast tumour. As hrt shortages continue to impact patients in the uk, we wanted to provide the most recent information regarding the availability of the evorel estradiol range of hrt products. Femseven sequi is a transdermal therapy comprising of 2 phases and is a continuous sequential hrt preparation.
Why supplies of hrt drugs are running low daily mail online. The levels of hormone from the patches are too low to act as a contraceptive. We recognise that many women are likely to experience difficulties in obtaining hrt supplies due to the current coronavirus situation. May 04, 2020 the british menopause society has issued this further update on the current availability of hrt products to provide guidance to bms members and clinical practitioners in response to the ongoing hrt shortages. It is not licensed for the prophylaxis of osteoporosis.
The phase two patches contain estradiol and levonorgestrel and are used for the last two weeks of every monthly cycle. For initiation and continuation of treatment of menopausal symptoms, the lowest effective dose for the shortest duration see also section 4. Transdermal contraceptive systems are popular, effective and convenient because they are applied once a week and associated with better compliance, especially in adolescents. Switch from c19 to c21 progestogens if pmslike symptoms andor androgenic sideeffects. One evorel sequi patch should be worn at all times, without interruptions. Femseven patches are a hormone replacement therapy hrt that add a hormone known as estradiol. Indications, side effects, contraindications and other prescribing information for femseven sequi on mims. When used correctly, the patch is more than 99% effective at preventing pregnancy.
Femseven sequi patches are a hormone replacement therapy hrt preparation. It is formulated as a transdermal patch and is the first sequential combined hrt patch to allow once weekly application. Evorel sequi is composed of evorel 50 and evorel conti. Accordingly, the following treatment cycle should be observed. Menopausal symptoms in women with a uterus whose last menstrual period occurred over 12 months previously. Hormone replacement therapy for oestrogen deficiency symptoms in postmenopausal women more than one year after menopause. You wear the patch on certain parts of your body, and it releases. Use nonhormonal contraceptive methods such as a condom, diaphragm or coil until your periods have completely stopped. Hrt does not provide contraception for women who fall within this. It is formulated as a transdermal patch and is the first continuous combined hrt patch to allow once weekly application. Thank you for reaching out to theramex medical information dept.
Women taking continuous combined transdermal hrt in the form of evorel conti patches who have difficulty obtaining supplies can consider the following alternatives below. Evorel sequi comes in a memory pack containing four evorel 50 patches marked ce50 and four evorel conti patches marked cen1. Appendix 12 hrt preparations west midlands menopause society. So, if a patch is applied once weekly femseven sequi or twice weekly evorel sequi, the patches they apply towards the second half of the month will contain different levels of hormones than those they apply at the start of the month. Stock update you are now leaving to an external website which is neither owned or controlled by theramex. Evorel 50 patches, which contain estradiol and evorel conti patches, which contain estradiol. Although mirena used for contraception is licensed for 5 years, the license for use for the progestogen part of hrt. The effect of mirena on the womb lining can significantly reduce bleeding and when used as part of an hrt regimen, in time, 30 to 60% of women have no bleeding at all.
They were first developed and released in the 2000s, and provide an alternative method of birth control for those who prefer not to swallow tablets, or may find it difficult or inconvenient taking a pill each day at the same time. Both estradiol products have been out of stock in the uk since the end of last year as a result of a quality issue with regards to the adhesive that keeps patches. Theramex sloane square house belgravia, london sw1w. Evorel sequi is a hormone replacement therapy hrt preparation. Hormone replacement therapy hrt is a treatment which replaces lower levels of female hormones as you approach the menopause, normally in your early 50s. Evorel conti estradiolnorethisterone patches and evorel estradiol 100. Femseven conti and femseven sequi transdermal patches are currently out of stock due to a supply problem with a component of the adhesive and there will be a period of testing before the transdermal patches.
Patients who have any questions with regards to their treatment options should speak to their general practitioner. Both types of patch are square with rounded corners. How to use estradiollevonorgestrel patch, transdermal weekly. Femseven sequi patches is not a transdermal contraceptive and does not prevent you from becoming pregnant. Aug 12, 2019 this includes combined oestrogen and progesterone patches, such as femseven conti and sequi. The patches contain two female hormones, estradiol and levonorgestrel. Medicinal forms there can be variation in the licensing of different medicines containing the same drug. So, if a patch is applied once weekly femseven sequi or twice weekly evorel sequi, the patches they apply towards the second.
The transdermal contraceptive patch is 20 cm roughly the size of a matchbook. Femseven sequi patches are used sequentially, meaning that during the first two weeks of each months, only patches containing estradiol synthetic oestrogen are used, with combined patches, containing. This is a sticky patch that is applied to the skin below the waist and left in place for seven days. A 2017 paper called magnesium in the gynecological practice. Femseven hormone replacement therapy hrt order online. Femseven conti patches do not interact with alcohol or affect your ability to drive safely. Each patch should be worn continuously for seven days. What femseven sequi, patch is and what it is used for femseven sequi is a sequential combined hormone replacement therapy hrt. Answering patients questions on intrauterine contraception. Menopause guidance on management and prescribing hrt. The transdermal contraceptive patch is a safe and convenient birth control method that works really well if you always use it correctly.
Transdermal estradiol 50mcg24hrs trandsermal norethisterone 170mcg24hrs for 14 days28. The currently available patch measures 4 cm by 5 cm 20 cm 2 and is composed of three layers. Read the patient information leaflet if available from your pharmacist before you start using this medication and each time you get a. Theres no reason to suffer through menopause when hormone replacement therapy is so good.
Shortage of hrts femseven conti and sequi expected until. It contains an oestrogen estradiol and a progestogen levonorgestrel. I have a call from the doctor this morning like gold dust round here had. Women who dont fall within this group should not use femseven conti patches if pregnant or breastfeeding. Each treatment cycle with femseven sequi consists of the successive application of two transdermal patches containing estradiol phase 1 and then two transdermal patches containing estradiol and levonorgestrel phase 2. If you require hormone replacement therapy tablets, our online pharmacy provides an online consultation with our gmc registered doctors.